1. Overview of Vaccine Adjuvants: Introduction, History, and Current Status Ruchi R. Shah, Kimberly J. Hassett, and Luis A. Brito 2. Development of the CpG Adjuvant 1018: A Case Study John D. Campbell 3. Syntheses of Human TLR8-Specific Small-Molecule Agonists Mallesh Beesu, Hari Prasad Kokatla, and Sunil A. David 4. Semisynthesis of Analogues of the Saponin Immunoadjuvant QS-21