Transcriptional and Epigenetic Mechanisms Regulating Normal and Aberrant Blood Cell Development

By Constanze Bonifer

Book Overview

Preface.- Introduction.- The epigenetic regulatory machinery by Constanze Bonifer and Peter N. Cockerill.- Non-mammalian hematopoiesis.- What can we learn from flies: Epigenetic mechanisms regulating blood cell development in Drosophila by Paul Badenhorst.- Epigenetic and transcriptional mechanisms regulating blood cell development in zebrafish by Xiaoying Bai.- Epigenetic mechanisms regulating mammalian hematopoietic stem cell development and function.- Epigenetic and transcriptional mechanisms regulating the development of the hematopoietic system in mammals by Maud Fleury, Flor M. Perez-Campo, Guilherme Costa, Georges Lacaud and Valerie Kouskoff.- Polycomb complexes: chromatin regulators required for cell diversity and tissue homeostasis by Miguel Vidal.- The role of polycomb group proteins in hematopoietic stem cell (HSC) self-renewal and leukemogenesis by Vincent van den Boom, Hein Schepers, Annet Z. Brouwers-Vos, and Jan Jacob Schuringa.- Role of the Trithorax (MLL) - HOX axis in HSC development, function and leukaemia by Robert Slany.- Role of DNA methyltransferases and DNA methylation in cell fate decisions during blood cell development and leukemia by Grant A. Challen and Jenny J. Trowbridge.- Epigenetic and transcriptional mechanisms regulating cell fate decisions and blood cell lineage development.- Transcriptional and epigenetic regulation in the development of myeloid cells: normal and diseased myelopoiesis by Peter Laslo and Tomas Stopka.- The molecular basis of normal Erythroid/Megakaryocyte development and mechanisms of epigenetic/transcriptional deregulation leading to erythroleukemia and thalassemia by Douglas Vernimmen.- The molecular basis of T cell development and how epigenetic/transcriptional deregulation leads to T-ALL by Will Bailis and Warren Pear.- Epigenetic control of T cell receptor locus rearrangements in normal and aberrant conditions by Beatriz del Blanco, ?rsula Angulo, and Cristina Hern?ndez-Munain.- The molecular basis of B cell development and the role of deregulated transcription and epigenetics in leukaemia and lymphoma by Christopher M. Kirkham, James N. Scott, Joan Boyes and Sarah Bevington.- Epigenetic control of immune cell function.- Epigenetic control of immune T cell memory by Atsushi Onodera, Damon J. Tumes, and Toshinori Nakayama.- The macrophage epigenome and the control of inflammatory gene expression by Sara Polletti, Alessia Curina, Gioacchino Natoli and Serena Ghisletti.- Subject index.

• Format: Hardcover
• Language: English
• ISBN: 3642451977
• ISBN13: 9783642451973
• Release Date: March 2014
• Publisher: Springer
• Length: 416 Pages
• Weight: 1.60 lbs.
• Dimensions: 1.3" x 6.4" x 9.2"