Topics in Medicinal Chemistry 4: Transporters as Targets for Drugs

By Matilda Bingham and Susan Napier

Book Overview

Overview: Transporters as Targets for Drug Discovery.- Membrane Transporters: Structure, Function and Targets for Drug Design.- Design of Monoamine Reuptake Inhibitors: SSRIs, SNRIs and NRIs.- Atypical Dopamine Uptake Inhibitors that Provide Clues About Cocaine's Mechanism at the Dopamine Transporter.- The Design, Synthesis and Structure-Activity Relationship of Mixed Serotonin, Norepinephrine and Dopamine Uptake Inhibitors.- Molecular Imaging of Transporters with Positron Emission Tomography.- Pharmacology of Glutamate Transport in the CNS: Substrates and Inhibitors of Excitatory Amino Acid Transporters (EAATs) and the Glutamate/Cystine Exchanger System x c ?.- Glycine Transporters and Their Inhibitors.

• Format: Paperback
• Language: English
• ISBN: 3642099696
• ISBN13: 9783642099694
• Release Date: October 2010
• Publisher: Springer
• Length: 254 Pages
• Weight: 0.84 lbs.
• Dimensions: 0.6" x 6.1" x 9.2"