Oxygen (O2) is a vital requisite for aerobic respiration in both eukaryotic and prokaryotic cells. Therefore, tissues or cell's ability to respond and adapt to oxygen tension is indispensable for the preservation of cellular homeostasis. Indeed, low partial O2 pressure-dependent fluctuations in oxygen levels lead to serious pathophysiological conditions. In general, hypoxia is a state in which the unavailability of sufficient amounts of oxygen...
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