The Regulation of Expression of Terminal Deoxynucleotidyl Transferase in an Inducible Murine Pre-B Cell Line

by Randy Horwitz

Abstract:

The purpose of this study was to understand the control of synthesis of Tdt at a molecular level, using a murine pre B-cell line inducible for the enzyme. FLEl-4, an Abelson virus transformed fetal liver cell line, when treated with dibutyryl cAMP and caffeine (or other phosphodiesterase inhibitors), shows a three- to tenfold induction of Tdt, as measured by immunoprecipitation of pulse labelled enzyme, activity assays, and steady-state...

• Format: Paperback
• Language: English
• ISBN: 0530018586
• ISBN13: 9780530018584
• Release Date: December 2019
• Publisher: Dissertation Discovery Company
• Length: 226 Pages
• Weight: 1.18 lbs.
• Dimensions: 0.5" x 8.5" x 11.0"