The Mechanism of Biochemical Action of Thyroid Hormones: Thyroid hormones in action

by Sami A. Al-Mudhaffar

Inosine mono phosphate (IMP) is a precursor of the two purine nucleotides, adenosine mono phosphate (AMP) and guanosine monophosphate (GMP): IMP -----adenylosuccinate ------AMP and IMP to xanthine monophosphate (XMP)---GMP. The reaction IMP----- adenylosuccinate is catalyzed by the enzyme synthetase which was purified and IMP---XMP is catalyzed by the enzyme IMP dehydrogenase which was purified also .Adenylosuccinate synthetase of rat liver is stimulated by L-T3 but not D-T4 and the effect of other analogues paralled their in vivo effects . The enzyme IMP dehydrogenase is inhibited by thyroid hormones, but not by D-T4, and also, the effects of other analogues paralled their in vivo effects.

• Format: Paperback
• Language: English
• ISBN: 1534949216
• ISBN13: 9781534949218
• Release Date: June 2016
• Publisher: Createspace Independent Publishing Platform
• Length: 164 Pages
• Weight: 0.74 lbs.
• Dimensions: 0.3" x 8.0" x 10.0"