The Ethics of Human Gene Therapy

By LeRoy Walters and Julie Gage Palmer

The authors of this absorbing new book describe the science of gene therapy in terms easily accessible to the non-specialist, and focus on the controversial ethical and public policy issues surrounding human interventions in human heredity. After a brief survey of the structure and functions of DNA, genes, and cells, Walters and Palmer discuss three major types of potential genetic intervention: somatic cell gene therapy, germ line gene therapy, and genetic enhancements. They start with the current techniques of gene addition, using non-reproductive (somatic) cells in an effort to cure or treat disease. Next they address the technical problems and moral issues facing attempts to prevent disease through genetically modifying early human embryos or sperm and egg cells. These changes would be passed on to future generations. Chapter 4, in many ways the most original part of this volume, confronts the issue of employing genetic means to improve human abilities and appearance. Depending on the techniques employed, such enhancements could affect not only the individuals receiving the intervention but their offspring as well. Three types of genetic enhancements are considered: physical alterations to improve size, reduce the need for sleep, and decelerate aging; intellectual enhancements of memory and general cognitive ability; and moral enhancements for control of violently aggressive behavior. The authors maintain that genetic modifications should be evaluated individually rather than be condemned in principle or as a group. The final chapter summarizes the public review process that human gene therapy proposals have been undergoing in the United States since 1990. Five appendices, providing technical background information along with a complete list of questions raised in the national public review process, supplement the discussion.

• Format: Hardcover
• Language: English
• ISBN: 0195059557
• ISBN13: 9780195059557
• Release Date: November 1996
• Publisher: Oxford University Press, USA
• Length: 232 Pages
• Weight: 1.30 lbs.
• Dimensions: 0.8" x 6.3" x 9.5"

Customer Reviews

Solid and compelling

Walters and Palmer present here a solid argument regarding the impending technology of human gene therapy. They walk through the science carefully, but the core of the book is on the development of criteria for when trials in gene therapy would be acceptable. While this reviewer does not agree with every stand they take, the book will be a classic in the ethics of gene therapy because of its careful argument and thorough analysis.