As his author himself has stated, this book is now out ofprint. As a researcher, I think this book is very useful, particularly to those who are just beginning their path in clinical trials; the book contains abundant information, as well as practical examples that make it easy to comprehend the basis of this kind of study; I think the chapter on sample size ism an especially interesting reading. In my opinion, this book deserves (and needs) a second edition, one in which some of the innovations could be included and some gaps could be filled; maybe a chapter about meta-analyses might be added.
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