Targeting the Wnt Pathway in Cancer

by Michael Kahn and Kathleen H. Goss

Inappropriate activation of the Wnt signaling pathway is observed in many human cancers and is sufficient to drive tumor initiation and progression in numerous contexts. Multiple mechanisms, such as overexpression of Wnt ligands, inactivation of the APC and Axin tumor suppressors, and mutation of -catenin, are responsible for pathway activation in tumor cells. The development of potent Wnt pathway antagonists for therapeutic use has been a...

• Format: Paperback
• Language: English
• ISBN: 1489981640
• ISBN13: 9781489981646
• Release Date: October 2014
• Publisher: Springer
• Length: 240 Pages
• Weight: 0.79 lbs.
• Dimensions: 0.5" x 6.1" x 9.2"