Sisters introduces us to a group of sisters, Alex (Swoosie Kurtz), Georgie (Patricia Kalember), Teddy (Sela Ward), Frankie (Julianne Phillips) and Charley (Jo Anderson & Sheila Kelley). They deal with life, love, children, death, divorce, marriage and virtually everything else. All through they are held together by their mother, Bea (Elizabeth Hoffman).