Since the advent of 5-HT3 receptor antagonists in the second half of the 1980s they have attained a pre-eminence in the prevention and treatment of nausea and vomiting caused by ionizing radiation and cytotoxic agents. This timely book reviews our understanding of the mechanisms and treatmentof nausea and vomiting in the light of the animal, pre-clinical and clinical data on the involvement of serotonergic pathways in this process, accumulated over the past 10 years. It brings together authors from a broad range of scientific and clinical disciplines to discuss the progress that hasbeen made and to predict where the future lies.
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