Part I: Computational Modeling and Imaging 1. Computational Modeling of the Dynamics of Spatiotemporal Rho GTPase Signaling: A Systematic Review Shabnam Khatibi, Karina Islas Rios, and Lan K. Nguyen 2. Uncovering Bistability in the Rac1/RhoA Signaling Network through Integrating Computational Modeling and Experimentation Alex von Kriegsheim and Lan K. Nguyen