This monograph is devoted to the development of the theory of pseudo-di?erential n operators on spaces with symmetries. Such spaces are the Euclidean space R, the n torus T, compact Lie groups and compact homogeneous spaces. The book consists of several parts. One of our aims has been not only to present new results on pseudo-di?erential operators but also to show parallels between di?erent approaches to pseudo-di?erential operators on di?erent spaces...