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Paperback Protein Homology Detection Through Alignment of Markov Random Fields: Using Mrfalign Book

ISBN: 331914913X

ISBN13: 9783319149134

Protein Homology Detection Through Alignment of Markov Random Fields: Using Mrfalign

This work covers sequence-based protein homology detection, a fundamental and challenging bioinformatics problem with a variety of real-world applications. The text first surveys a few popular homology detection methods, such as Position-Specific Scoring Matrix (PSSM) and Hidden Markov Model (HMM) based methods, and then describes a novel Markov Random Fields (MRF) based method developed by the authors. MRF-based methods are much more sensitive than...

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