Pharmaco-Complexity : Non-Linear Phenomena and Drug Product Development

By Hugh D.C. Smyth and Anthony J Hickey

1. Introduction

The nature of complexity and relevance to the pharmaceutical sciences

2. Chemistry and Thermodynamics

Chemical Reactions Surface and Interfacial Chemistry

i. Aggregation

ii. Protein Structure

iii. Receptor Interactions

Statistical Mechanics

Solid State

3.1 Statics

Morphology Association Population Structure 3.2 Dynamics

a Aggregation

b. Flow

c. Dispersion

4. Quality by Design

4.1 Statistics and Experimental Design

4.2 Process Design and Control

4.3 Risk Assessment and Management

5. Pharmacokinetics and Pharmacodynamics

5.1 Pharmacokinetics/Toxicokinetics

a. Physiologically relevant modeling

b. Compartmental Modeling

5.2 Efficacy/Safety

a. Indirect measures of pharmaco-/toxico-dynamics

b. Direct measures of pharmaco-/toxico-dynamics

Population Biology

Incidence of disease Intervention

Machine Learning

Models

i. Stochastic

ii. Deterministic

iii. Neural Networks

Data Mining, correlations and AI Conclusion

References

Index.

• Format: Hardcover
• Language: English
• ISBN: 303042782X
• ISBN13: 9783030427825
• Release Date: June 2020
• Publisher: Springer
• Length: 70 Pages
• Weight: 0.65 lbs.
• Dimensions: 0.3" x 6.1" x 9.2"