In 1719, a deadly and highly contagious disease took hold of the Imperial Villa of Potos , a silver mining metropolis in what is now Bolivia. Within a year, the pathogen had killed some 22,000 people, just over a third of the city's residents. Victims collapsed with fever, body aches, and effusions of blood from the nose and mouth. Most died within days. The great Andean pandemic of 1717-22 was likely the most destructive disease to strike South...
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