This volume presents, with some amplification, the notes on the lectures on nuclear physics given by Enrico Fermi at the University of Chicago in 1949. "The compilers of this publication may be warmly congratulated. . . . The scope of this course is amazing: within 240 pages it ranges from the general properties of atomic nuclei and nuclear forces to mesons and cosmic rays, and includes an account of fission and elementary pile theory. . ...