New Horizons in Predictive Drug Metabolism and Pharmacokinetics

By Alan G.E. Wilson

This book will present a comprehensive treatise by leading experts on the current issues and challenges facing drug metabolism and pharmacokinetics and their predictive role in impacting drug discovery and development. Authors will not only focus on the current state of art, with distinct examples, but on future needs and approaches likely to improve our prediction of potential human risk. A discussion of the critical properties that are determinants of a compound's metabolic and pharmacokinetic fate will follow the introductory chapters. The focus of the following chapters will reflect the increasing interest in assessing the role of drug transporters and drug metabolising enzymes as potential determinants of pharmacokinetic behavior and the increase in in silico and computational approaches. Lastly, chapters will cover the issues and factors involved in translating pharmacokinetics from in silico to in vivo and from animal models to man, and will cover future directions and opportunities.

• Format: Hardcover
• Language: English
• ISBN: 1849738289
• ISBN13: 9781849738286
• Release Date: November 2015
• Publisher: Royal Society of Chemistry
• Length: 434 Pages
• Weight: 1.80 lbs.
• Dimensions: 1.1" x 6.4" x 9.3"