INTRODUCTION The history of substance use is as old as the history of mankind; hence it is not a recent phenomenon. Some drugs have been used for religious purposes in ancient times; priests and shamans have consumed plants for epochs to bring a state of dissociative trance. This group of substances is sometimes labeled as "entheogenic". In central Asia, a mushroom called Amanita muscaria; (agaric) has been used for at least 4000 years for religious...