This book is indispensable to researchers in fields as diverse as molecular biology and biophysics. It is an essential text for university libraries, covering as it does the important role that mitochondria play in a variety of biochemical spheres. The work has been co-authored by two leading figures in the field of biomedical research. In it, they analyse how mitochondria affect metabolic pathways, how they are active in the regulation of cytosolic constituents, and their role in initiating signal pathways. Also covered are the way mitochondria help to regulate apoptosis, and how they modulate cellular hypertrophy and proliferation. It gives an overview of the emergence of mitochondria as an important regulator of cell signaling, with a particular focus on their pathophysiology.