Psoriasis is a chronic inflammatory disease with a major impact on the quality of life of patients. Its management remains a real challenge. The aim of our study is to evaluate the place of methotrexate in the treatment of moderate to severe psoriasis in our Moroccan context. We obtained good results with a complete remission in 50% of the cases, with few side effects thanks to a regular follow-up of our patients, as well as their supplementation...