Part I: Concepts 1. Protein Misfolding and Cellular Stress: An Overview Niels Gregersen and Peter Bross 2. Protein Aggregation Diseases: Toxicity of Soluble Prefibrillar Aggregates and Their Clinical Significance Massimo Stefani 3. Consequences of Stress in the Secretory Pathway: The ER Stress Response and Its Role in the Metabolic Syndrome Martin Schr?der and Louise Sutcliffe 4. What Role Does Mitochondrial Stress Play in Neurodegenerative Diseases?...