Lasso Peptides: Bacterial Strategies to Make and Maintain Bioactive Entangled Scaffolds

by Sylvie Rebuffat, Severine Zirah, Yanyan Li

Lasso peptides form a growing family of fascinating ribosomally-synthesized and post-translationally modified peptides produced by bacteria. They contain 15 to 24 residues and share a unique interlocked topology that involves an N-terminal 7 to 9-residue macrolactam ring where the C-terminal tail is threaded and irreversibly trapped. The ring results from the condensation of the N-terminal amino group with a side-chain carboxylate of a glutamate...

• Format: Paperback
• Language: English
• ISBN: 1493910094
• ISBN13: 9781493910090
• Release Date: October 2014
• Publisher: Springer
• Length: 103 Pages
• Weight: 0.39 lbs.
• Dimensions: 0.3" x 6.1" x 9.2"