The Basic Components of Seismo-Ionospheric Coupling.- Ionospheric Precursors of Earthquakes as they are seen from the Ground and from Space.- Near Ground and Troposphere Plasmachemistry and Electric Field.- Physics of Seismo-Ionospheric Coupling.- Main Phenomenological Features of Ionospheric Precursors of Earthquakes.- Are we Ready for Prediction? The Practical Applications.- Ultimate Results, Unexplained Phenomena, Future Tasks.