Heat stress (HS) induces the production of oxygen-derived free radicals, which are associated with negative effects on the physiology, health, and productivity of dairy cows. In order to compare physiological and productive variables of Holstein cows in summer and winter under arid region conditions, 40 lactating multiparous cows (100 to 150 d in milk) were randomly selected in a representative month of each season (n=20/season). Data were analyzed...