Part 1. Design and Engineering.- Chapter 1. Concept Design: Modeling and Synthesis from Requirements to Functional Models and Simulation.- Chapter 2. Platform-Based Design for Automotive and Transportation Cyber-Physical Systems.- Chapter 3. An Hourglass-Shaped Architecture for Model-Based Development of Networked Cyber-Physical Systems.- Part 2. Testing and Operation.- Chapter 4. Formal Techniques for Verification and Testing of Cyber-Physical Systems.- Chapter 5. Data-driven Safety Verification of Complex Cyber-Physical Systems.- Chapter 6. System Assurance in the Design of Resilient Cyber-Physical Systems.- Part 3. Application-Specific Design Automation Methodologies and Tools.- Chapter 7. Optimal Design of Distributed Controllers for Large-Scale Cyber-Physical Systems.- Chapter 8. Model-driven Software Design Automation for Complex Rehabilitation.- Chapter 9. Design Automation using Structural Graph Convolutional Neural Networks.- Chapter 10. Design Automation for Energy Storage Systems.