The only known stocks of smallpox lie in deep freeze at the Center for Disease Control in Atlanta and the Vector Virology lab in Siberia. So who released the deadly virus in New York City in time for the holidays? The city is locked down and teeters on the brink of an economic free fall and it is up to disease detective Mackey Dunn and FBI Agent Charo Chen to solve the outbreak and criminal case before the US starts another war and smallpox resumes...