Computational & Structural Analysis of Anti-Alzheimer's Compounds
Alzheimer's disease is a neurodegenerative disorder that affects millions of people worldwide. It is characterized by the accumulation of beta-amyloid and tau protein in the brain, leading to protein aggregation, neuronal death, and cognitive decline. To combat this disease, researchers are exploring the use of anti-Alzheimer's compounds, which can target various aspects of the disease, including protein aggregation, inflammation, and oxidative stress.
In this book, "Computational & Structural Analysis of Anti-Alzheimer's Compounds," author M Sivakumar delves into the latest research on these compounds, using computational and structural analysis techniques to explore their potential as therapeutic agents. The book covers a range of topics, from molecular modeling and docking to pharmacophore modeling and virtual screening. The author also discusses the role of neuroprotection in Alzheimer's disease, as well as the importance of the blood-brain barrier in drug design.
Throughout the book, the author highlights key compounds that have shown promise in combating Alzheimer's disease, including cholinesterase inhibitors, anti-inflammatory agents, and antioxidants. The book also covers natural products, such as polyphenols, flavonoids, terpenoids, alkaloids, and curcuminoids, which have gained attention for their potential neuroprotective effects.
Overall, "Computational & Structural Analysis of Anti-Alzheimer's Compounds" is a comprehensive guide for researchers and clinicians interested in the latest developments in Alzheimer's disease therapy. It covers both computational and experimental aspects of drug design, providing valuable insights into the structural activity relationship, toxicity, metabolism, bioavailability, and pharmacokinetics of anti-Alzheimer's compounds.
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