Clamp Loader of Escherichia Coli Dna Polymerase III: Kinetics of the Atp-dependent Steps in the Sliding-clamp Loading Reaction

by Christopher Williams

Abstract:

Sliding clamps tether DNA polymerases to DNA to increase the processivity of synthesis. The Escherichia coli γ complex loads the β sliding clamp onto DNA in an ATP-dependent reaction in which ATP binding and hydrolysis modulate the affinity of the γ complex for β and DNA. This dissertation covers research describing the kinetic mechanism of clamp loading by gamma complex.

Dissertation Discovery Company and...

• Format: Hardcover
• Language: English
• ISBN: 0530004690
• ISBN13: 9780530004693
• Release Date: May 2019
• Publisher: Dissertation Discovery Company
• Length: 624 Pages
• Weight: 3.78 lbs.
• Dimensions: 1.3" x 8.5" x 11.0"