Wieland suggests four basic books if one is to research supplements. He then describes the key physiological mechanisms on which supplements operate: (1) Differentiation or normalizing cancerous tissues, (2) Apoptosis or programmed cell death of cancer cells, (3) COX-2, elimination of dangerous inflammation, (4) Angiogenesis or the growth of new blood vessels by tumors, (5) 5-LOX, an inflammatory enzyme that fosters the progression of cancer, (6) NF-kB, the protection of cancer cells against the body's normal defense mechanisms. Wieland's four main strategies in his fight against cancer were: (1) Synergies or multiple supplements in low doses rather than just a few supplements at high doses, (2) Multiple inexpensive supplements rather than fewer that are expensive, (3) Whole herb extracts that include a host of anti-cancer ingredients rather than purified extracts of a single anti-cancer ingredient. (4) Use of repeated laboratory tests to see if various supplements are working, or not. The bulk of the book is an account of the 37 supplements Wieland used to fight his cancer, including the dosages for each as well as different cancers they act upon.
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