Holden McNeil (Ben Affleck) and Banky Edwards (Jason Lee) are comic book artists and lifelong best friends. They meet fellow comic book artist Alyssa Jones (Joey Lauren Adams) at a comic book convention in New York City, where they are promoting their comic Bluntman and Chronic. Holden is attracted to Alyssa, but soon learns that she is a lesbian. The two begin spending time together, and a deep friendship develops. Eventually, Holden is no longer...