Professor Castillo's daughter Valeria Renner, has mysteriously disappeared into the Amazon jungle. Determined to find her, he begs Ulysses and Cassie to go with him. Unable to dissuade him and not wanting to go on his own, they both accept to help their old frien in his crazy attempt to rescue Valeria. The three will embark on an incredible journey to a place that should not exist, the Lost City of Z. A journey nobody has ever returned from.