While CAV1 expression in cardiomyocytes has remained controversial,18,19,20,21 CAV1 knock-out mice were associated with a phenotype of cardiac hypertrophy.100,101 Importantly, the hypertrophic heart changes in CAV1 knock-out mice were solely related to cardiac fibroblasts and endothelial cells.100,101 Since CAV1 was shown to inhibit the enzymatic nitric oxide synthase (NOS) function through direct protein interactions102, it is interesting that increased...