Activation-Induced Deaminase: On the Targeting Mechanism of Aid to the Immunoglobulin Loci

by Andrew Franklin

During the course of the immune response, antigen-activated B cells produce antibodies with increased affinity for the antigen, a process called affinity maturation. A host produces antibodies with successively greater affinities with repeated exposure to the same antigen, which is the principle by which most vaccines work. Affinity maturation relies on hypermutation, an iterative process of mutation at antibody-encoding genes, followed by positive...

• Format: Hardcover
• Language: English
• ISBN: 3110459957
• ISBN13: 9783110459951
• Release Date: February 2018
• Publisher: de Gruyter
• Length: 140 Pages
• Grade Range: Postsecondary