Sickness is ravaging America, driving the infected to savagery. Petty criminal Ben Silensky is determined to get his girlfriend Carlita and son Kyle free of the quarantined city they live in, enough so to risk a foolhardy crime and then to team up with Carlita's equally desperate cop cousin Nando. Once they're out, Nando is certain they'll find a place in the open prison where his uncle works, unbeknownst to him already become a survivalist colony...